https://natural-sciences.nwu.ac.za/mitochondrial-laboratory/research-objectives-and-technologies-used
Research Objectives and Technologies Used
The MRL is set up to investigate various aspects of mitochondrial function and disease from different approaches and is therefore a truly multidisciplinary research group. The laboratory is a very well-equipped with specialised apparatus for the following: Mitochondrial function: Mitochondrial oxidative…https://natural-sciences.nwu.ac.za/mitochondrial-laboratory/current-research-activities-and-developments
Current Research Activities and Developments
The current projects of the MRL fall into three groups: Mitochondrial disorders in the SA population: molecular genetics and metabolomics Cohort investigations with national and international researchers and clinicians Adaptive responses in mitochondrial dysfunction…https://natural-sciences.nwu.ac.za/mitochondrial-laboratory/publications
Publications
Our publications are listed in order of the most relevant over the last five years: Reinecke CJ, Koekemoer G, van der Westhuizen FH, Louw R, Lindeque JZ, Mienie LJ, Smuts I. 2012. Metabolomics of urinary organic acids in respiratory chain deficiencies. Metabolomics 8, 264-283 (IF 4.505). van der Walt EM, Smuts I,…https://natural-sciences.nwu.ac.za/human-and-animal-genetics/research-leaders-and-publication-links
Research Leaders and Publication Links
Dr Rencia van der Sluis Senior Lecturer Research: Orcid | Scopus Telephone: +27 18 299 2068 E-mail: 21224919@nwu.ac.za Office: Potchefstroom Campus, Building F3, Room 108 Qualifications: PhD…https://natural-sciences.nwu.ac.za/human-and-animal-genetics/active-researchers
Active Researchers
Dr Henriette van der Zwan Postdoctoral Fellow Orcid Mr Stauss van Graan MSc Student Orcid Mr Pieter Lourens MSc Student Orcid …https://natural-sciences.nwu.ac.za/human-and-animal-genetics/background-research
Background to the Research
Within the group, we have two main focus areas namely the characterisation of the glycine conjugation pathway as well as the development of molecular diagnostic tests for application in animal breeding. a) Genetic and enzymatic characterisation of the glycine conjugation pathway – a phase II detoxification pathway. Benzoate (found…https://natural-sciences.nwu.ac.za/molecular-biology/research-group
History to the Group
The Molecular Biology group is one of the specialised research groups within the Focus Area for Human Metabolomics. Molecular biology is the branch of biology that seeks to understand the molecular basis of biological activity in and between cells, including biomolecular synthesis, modification, mechanisms, and interactions. The following three…https://natural-sciences.nwu.ac.za/human-and-animal-genetics/pastformer-members
Past/former Members
Miss H van der Zwan (PhD 2015-2019) Ms V Ungerer (MSc 2014 – 2015) Ms T van der Westhuizen (MSc 2014 – 2015) Ms C Nortje (MSc 2013 – 2015) Mr P Venter (MSc 2017-2018) Mr DM de Villiers (MSc 2016-2019) Ms C Schutte (MSc 2017-2019) Ms C Moolman (PhD 2021) Mr Geldenhuys (MSc 2021)https://natural-sciences.nwu.ac.za/biotransformation-and-oxidative-stress-status-laboratory/research-leaders-and-publication-links
Research Leaders and Publication Links
Prof. E. Erasmus Professor (Biochemistry) Research: Orcid Telephone: +27 18 299 2305 E-mail: Lardus.Erasmus@nwu.ac.za Office: Potchefstroom Campus, Building F3, Room 121 Qualifications: PhD Professional registration: Medical Biological Scientist at Health…https://natural-sciences.nwu.ac.za/biotransformation-and-oxidative-stress-status-laboratory/contact-us
Contact us
Postal Address: Private Bag X 6001 Potchefstroom 2520 South Africa Physical Address: Biotransformation and Oxidative Stress Laboratory Building F3 – Biochemistry …https://natural-sciences.nwu.ac.za/biotransformation-and-oxidative-stress-status-laboratory/active-researchers-and-publication-links
Active Researchers and Publication Links
Mr Peet Jansen van Rensburg Extraordinary Senior Lecturer Orcid Ms Carien van der Berg Laboratory Technician and Manager Orcid Ms Tarien Jacobs Laboratory Technician Orcid Mr Ruhan van Huyssteen MSc Student Orcid…https://natural-sciences.nwu.ac.za/biotransformation-and-oxidative-stress-status-laboratory/funders
Funders
TIA (Technology Innovation Agency; 2011 - 2014) CANSA (Cancer Association of South Africa; 2016-2019) NRF (National Research Foundation; 2022-2024)https://natural-sciences.nwu.ac.za/biotransformation-and-oxidative-stress-status-laboratory/history-research-group
History of the Research Group
Based on the high incidence of Chronic Fatigue Syndrome amongst the clinically referred patients, and the role that biotransformation analysis may play to contribute to improved treatment and prognosis of chronic fatigue induced conditions, this TIA / CareDoc / NWU initiative was launched in 2013. Since then, the analysis platforms have expanded…https://natural-sciences.nwu.ac.za/biotransformation-and-oxidative-stress-status-laboratory/research-background
Research Background
Monitoring of biotransformation reactions are becoming increasingly relevant as the impact of xenobiotics on the metabolism is beginning to unfold and correlations are found between the production of certain biotransformation products and the development of certain cancers. The complex systems of detoxification enzymes generally function…https://natural-sciences.nwu.ac.za/biotransformation-and-oxidative-stress-status-laboratory/research-objectives-and-technologies-used
Research Objectives and Technologies Used
The BOSS research group at the NWU has been involved in the development of a metabolomics approach for the analysis of biotransformation biomarkers. In this approach, targeted analysis of specific biomarkers for biotransformation is used to determine whether abnormalities in these metabolic pathways occur, what the magnitude of these…https://natural-sciences.nwu.ac.za/biotransformation-and-oxidative-stress-status-laboratory/current-research-activities-and
Current Research Activities and Developments
Service Delivery: The biotransformation status of clinically referred patients is currently monitored as part of a Biotransformation test package offered by the Centre for Human Metabolomics at the North-West University. The purpose of these tests is to monitor the liver’s reaction to a number of challenge substances. In doing this,…https://natural-sciences.nwu.ac.za/biotransformation-and-oxidative-stress-status-laboratory/publications
Publications
C. Petrus, S. Badenhorst, R. Van Der Sluis, Glycine conjugation : importance in metabolism , the role of glycine N -acyltransferase , and factors that influence interindividual variation, (2013) 1–15. C.P.S. Badenhorst, E. Erasmus, R. van der Sluis, C. Nortje, A.A. van Dijk, A new perspective on the importance of glycine…https://natural-sciences.nwu.ac.za/laboratory-infectious-and-acquired-diseases/research-leaders-and-publication-links
Research Leaders and Publication Links
Prof. Du Toit Loots Professor Research: Orcid | Scopus Telephone: +27 18 299 1818 E-mail: dutoit.loots@nwu.ac.za Office: Potchefstroom Campus, Building F3, Room 111 Qualifications: PhD Expertise: Infectious Disease Metabolomics …https://natural-sciences.nwu.ac.za/laboratory-infectious-diseases/contact-us
Contact us
General Contact: Postal Address: Private Bag X 6001 Potchefstroom 2520 South Africa Physical Address: Focus Area for Human Metabolomics Building F3 – Biochemistry North-West University…https://natural-sciences.nwu.ac.za/laboratory-infectious-and-acquired-diseases/active-researchers-and-publication-links