http://natural-sciences.nwu.ac.za/biotransformation-and-oxidative-stress-status-laboratory/research-background
Research Background
Monitoring of biotransformation reactions are becoming increasingly relevant as the impact of xenobiotics on the metabolism is beginning to unfold and correlations are found between the production of certain biotransformation products and the development of certain cancers. The complex systems of detoxification enzymes generally function…http://natural-sciences.nwu.ac.za/biotransformation-and-oxidative-stress-status-laboratory/research-objectives-and-technologies-used
Research Objectives and Technologies Used
The BOSS research group at the NWU has been involved in the development of a metabolomics approach for the analysis of biotransformation biomarkers. In this approach, targeted analysis of specific biomarkers for biotransformation is used to determine whether abnormalities in these metabolic pathways occur, what the magnitude of these…http://natural-sciences.nwu.ac.za/biotransformation-and-oxidative-stress-status-laboratory/current-research-activities-and
Current Research Activities and Developments
Service Delivery: The biotransformation status of clinically referred patients is currently monitored as part of a Biotransformation test package offered by the Centre for Human Metabolomics at the North-West University. The purpose of these tests is to monitor the liver’s reaction to a number of challenge substances. In doing this…http://natural-sciences.nwu.ac.za/biotransformation-and-oxidative-stress-status-laboratory/publications
Publications
C. Petrus, S. Badenhorst, R. Van Der Sluis, Glycine conjugation : importance in metabolism , the role of glycine N -acyltransferase , and factors that influence interindividual variation, (2013) 1–15. C.P.S. Badenhorst, E. Erasmus, R. van der Sluis, C. Nortje, A.A. van Dijk, A new perspective on the importance of…http://natural-sciences.nwu.ac.za/laboratory-infectious-and-acquired-diseases/research-leaders-and-publication-links
Research Leaders and Publication Links
Prof. Du Toit Loots Professor Research: Orcid | Scopus Telephone: +27 18 299 1818 E-mail: dutoit.loots@nwu.ac.za Office: Potchefstroom Campus, Building F3, Room 111 Qualifications: PhD Expertise: Infectious Disease Metabolomics…http://natural-sciences.nwu.ac.za/water-research-group-phd
Doctoral Students
Current research focus: Trypanosomes, blood parasites, Environment, marine and freshwater fish, life-cycle stages, diversity. Overview: Chandra is starting her Ph.D. in 2025. She obtained her Master’s degree in 2024 with distinction at the NWU Potchefstroom Campus. Chandra also obtained her undergraduate B.Sc.…http://natural-sciences.nwu.ac.za/water-research-group-msc
Master's Students
Angela Minnie Email address: 30488222@mynwu.ac.za Current research focus: Acanthocephala, Taxonomy, Marine environmental parasitology, Biological indicators. Overview: Angela Minnie graduated with a B.Sc. in Microbiology and…http://natural-sciences.nwu.ac.za/water-research-group-postdocs
Postdoctoral fellows
Dr Anja Erasmus Email address: 23599235@mynwu.ac.za Field of expertise: Gnathiidae, Integrated Taxonomy, Scientific Illustration, Environmental parasitology Overview: Anja is currently serving as a Postdoctoral Research Fellow…http://natural-sciences.nwu.ac.za/laboratory-infectious-diseases/contact-us
Contact us
General Contact: Postal Address: Private Bag X 6001 Potchefstroom 2520 South Africa Physical Address: Focus Area for Human Metabolomics Building F3 – Biochemistry …http://natural-sciences.nwu.ac.za/laboratory-infectious-and-acquired-diseases/active-researchers-and-publication-links
Active Researchers and Publication Links
Dr Adetomiwa Adeniji Postdoctoral Fellow Orcid Mr Tumelo Kgoe PhD Student Orcid Mr Simon Isaiah PhD Student Orcid…http://natural-sciences.nwu.ac.za/laboratory-infectious-diseases/funders
Funders
Mr. Simon Isaiah was awarded the NRF-NUFFIC (split–site) Doctoral Scholarship on 10 September 2019. This 4-year scholarship is aimed at a joint PhD degree between the North-West University and Vrije University Medical Centre in which Mr Isaiah will work closely with Dutch collaborators by means of two 1-month period visits to the…http://natural-sciences.nwu.ac.za/laboratory-infectious-diseases/collaborators
Collaborators
Our collaborators and/or coinvestigators are as follows: HIV studies: Prof. Thumbi Ndung'u, Director, HIV Pathogenesis Programme, Doris Duke Medical Research Institute, Nelson R. Mandela School of Medicine, University of KwaZulu-Natal, Durban, South Africa Prof. Carina Mels, Hypertension in Africa Research Team (HART…http://natural-sciences.nwu.ac.za/laboratory-infectious-diseases/history-group
History to the Group
The establishment of the National Metabolomics platform at the NWU encompassed both the Focus Area: Human Metabolomics (FHM) and the Centre for Human Metabolomics (CHM). The focus area primarily performs research while the CHM commercialises the developed methods and/or findings.In 2008, the Technology Innovation Association (TIA) aimed…http://natural-sciences.nwu.ac.za/laboratory-infectious-and-acquired-diseases/background-research
Background to the Research
The human immunodeficiency virus (HIV), the causative agent of acquired immunodeficiency syndrome (AIDS), impacts both the immune and metabolic systems of its host, ultimately affecting disease pathogenesis. Viral dormancy further complicates the eradication of the HIV/AIDS pandemic. Apart from the development of HIV and/or treatment-associated…http://natural-sciences.nwu.ac.za/laboratory-infectious-and-acquired-diseases/formerpast-members
Former/Past Members
Dr Zinandré Stander (PhD/Postdoc, 2021) D.W. Mulder (PhD, 2019) M.M. Phiri (PhD, 2019) B. Malatji (PhD, 2017) C. Irwin (PhD, 2017) K. Esterhuizen (PhD, 2017) L. Luies (PhD, 2017) L. Venter (PhD, 2017) I. Olivier (PhD, 2012) L. Davis (PhD, 2010) P.T. Pisa (PhD, 2009) N…http://natural-sciences.nwu.ac.za/laboratory-infectious-diseases/news-social-updates-gallery
News, Social Updates & Gallery
The members of our group form part of Metabolomics South Africa, actively engage in workshops, conferences and community engagement projects and as a result are recognised for their contributions both locally and internationally. Some of the links and or pictures are exemplary of some of the activities/events which they partake in. Also…http://natural-sciences.nwu.ac.za/laboratory-infectious-diseases/publications
Publications
Prof Du Toit Loots’ publications (last 5 years) I. Olivier, D.T. Loots. 2012. A metabolomics approach to characterise and identify various Mycobacterium species. Journal of Microbiological Methods, 88: 419-426. Impact factor 2.2 I. Olivier, D.T. Loots. 2012. Altered fatty acid metabolism due to rifampicin-…http://natural-sciences.nwu.ac.za/biologiese-wetenskappe/nuus