http://natural-sciences.nwu.ac.za/focus-area-human-metabolomics/about-us
About us
History In 2006, Biopad, as subsidiary of the Technology Innovation Agency (TIA), was tasked with the establishment of ‘omics’ technology in South Africa. Through the initiatives of Prof Carolus Reinecke, the NWU biochemistry group was selected to host the metabolomics platform due to the extensive expertise of the group in…http://natural-sciences.nwu.ac.za/mitochondria-research-laboratory/active-researchers
Active Researchers
Dr Maryke Schoonen Laboratory Manager Orcid Dr Karin Terburgh Postdoctoral Fellow Orcid Dr Tendai Makwikwi Postdoctoral Fellow Orcid Dr Roksana Majewska PhD Student Orcid…http://natural-sciences.nwu.ac.za/mitochondria-research-laboratory/collaborators
Collaborators
National: Prof Izelle Smuts & Dr Kealeboga Rammego, Department of Paediatrics & Steve Biko Akademic Hospital, University of Pretoria; Prof Jo Wilmshurst, Mrs Surita Meldau, Dr Gill Riordan, Department of Paediatric Neurology, Red Cross War Memorial Children’s Hospital, and NHLS Laboratory at the University of Cape Town…http://natural-sciences.nwu.ac.za/mitochondria-research-laboratory/history-research-group
History of the Research Group
The group was formed in 2001 with the aim of forming a specialist research group to study and provide biochemical diagnostic capacity for mitochondrial- and other inherited metabolic diseases in South Africa. Over two decades this research aim expanded in scope to now include a wide range of investigations in several types of disease…http://natural-sciences.nwu.ac.za/mitochondria-research-laboratory/background-research
Background to the Research
With the background and expertise of the division of Biochemistry in inherited metabolic diseases and metabolism, the research topics of the group are structured around the involvement of the mitochondrial oxidative phosphorylation (OXPHOS) system in human diseases. Defects in the mitochondrial energy metabolism is not only the largest group of…http://natural-sciences.nwu.ac.za/mitochondrial-laboratory/research-objectives-and-technologies-used
Research Objectives and Technologies Used
The MRL is set up to investigate various aspects of mitochondrial function and disease from different approaches and is therefore a truly multidisciplinary research group. The laboratory is a very well-equipped with specialised apparatus for the following: Mitochondrial function: Mitochondrial…http://natural-sciences.nwu.ac.za/mitochondrial-laboratory/current-research-activities-and-developments
Current Research Activities and Developments
The current projects of the MRL fall into three groups: Mitochondrial disorders in the SA population: molecular genetics and metabolomics Cohort investigations with national and international researchers and clinicians Adaptive responses in…http://natural-sciences.nwu.ac.za/mitochondrial-laboratory/publications
Publications
Our publications are listed in order of the most relevant over the last five years: Reinecke CJ, Koekemoer G, van der Westhuizen FH, Louw R, Lindeque JZ, Mienie LJ, Smuts I. 2012. Metabolomics of urinary organic acids in respiratory chain deficiencies. Metabolomics 8, 264-283 (IF 4.505). van der Walt EM…http://natural-sciences.nwu.ac.za/human-and-animal-genetics/research-leaders-and-publication-links